Effects Of Growth Hormone On Bone Modeling, Hypophysectomized Female Rats By Lysette Iglesias
FOR IMMEDIATE RELEASE
Miami Lakes, Florida (January 17, 2015):-
Abstract: Growth hormone (GH) deficiency causes decreased bone mineral
density and osteoporosis, predisposing to fractures. We investigated the
mechanism of action of GH on bone modeling and remodeling in
hypophysectomized (HX) female rats. Thirty female Sprague–Dawley rats at
age 2 months were divided into three groups with 10 rats each: control
(CON) group, HX group, and HX + GH (3 mg/kg daily SC) group, for a
4-week study. Hypophysectomy resulted in cessation of bone growth and
decrease in cancellous bone mass. Periosteal bone formation decreased
and bone turnover rate of endocortical and trabecular surfaces increased
as compared to the CON group. GH administration for 4 weeks restored
weight gain and bone growth and mitigated decrease in bone density after
hypophysectomy.
However, trabecular bone mass in the proximal
tibial metaphysis remained lower in group HX + GH than in group CON.
Dynamic histomorphometric analysis showed that bone modeling of
periosteal bone formation and growth plate elongation was significantly
higher in group HX + GH than in group HX. New bone formed beneath the
growth plate was predominately woven bone in group CON and group HX +
GH. Bone remodeling and modeling–remodeling mixed modes in the
endocortical and PTM sites were enhanced by GH administration; both bone
formation and resorption activities were significantly higher than in
group HX. In conclusion, GH administration to HX rats reactivated
modeling activities in modeling predominant sites and increased new bone
formation. GH administration also increases remodeling activities in
remodeling predominant sites, giving limited net gain in the bone mass.
To
read the complete study please visit the links mentioned above. The
abbreviations used in this study are described in front of them in the
initial paragraph for example: Growth hormone (GH), hypophysectomized
(HX), Control (CON).
Resource:
The Japanese Society for Bone and Mineral Research and Springer.
Resource:
http://lysetteiglesiasmd.com
http://lysetteiglesiasmd.com/pc/e55fvux17
About Lysette Iglesias MD:
Dr.
Lysette Iglesias' goal is to provide state-of-the-art pediatric
endocrine, obesity and diabetes care in an efficient and family-friendly
environment. Dr. Lysette Iglesias is licensed to practice medicine in
both New York and Florida, as well as in Costa Rica.
Media Contact:
Lysette Iglesias MD
Tel.: + 1 305 381 5301
Fax. + 1 305 381 5541
E-mail: info@lysetteiglesiasmd.com
###